Clinical module
Every embryo, every day, on one record
FertiliCore gives the IVF laboratory one record per embryo, carrying its source oocyte, its day-by-day culture and grading log, and its final disposition. Grading uses seeded day-2, day-3 and day-4 catalogues and structured Gardner expansion, ICM and trophectoderm fields rather than free text. Embryo transfer and embryo thaw are recorded as their own screens.
- One record per embryo, from oocyte to disposition
- Daily grading grid covering days 2 to 6
- Gardner expansion, ICM and trophectoderm as separate fields
- Seeded day-2, day-3 and day-4 grade catalogues
The session is the lab's summary of one retrieval
Every oocyte retrieval opens a piece of laboratory work: a cohort of oocytes, an insemination decision, and a fertilisation check the following morning. FertiliCore models that as an embryology session tied to the OPU and the treatment cycle, so the maturity breakdown and the fertilisation outcome stay attached to the retrieval that produced them rather than being reconstructed later from embryo rows. The session record captures the insemination method and sperm source, the MII, MI, GV and degenerate counts, and the split between normally fertilised 2PN oocytes and abnormal fertilisation. Each embryo created that day is attached to its session when the embryo record is created, which is what makes fertilisation rate a derived figure instead of a hand-tallied one.
The embryo record is the identity card
An embryo accumulates facts over a week of culture and often over years of storage, and those facts have to survive staff changes and cycle boundaries. The embryo record holds the durable summary: its sequence number within the session, the maturity of the oocyte it came from, the sperm source and the morphology and motility of the sperm used, the final grade and the day that grade was assigned, the PGT result once genetics returns it, the freeze day and method, thaw and transfer dates, and the final disposition. The embryology screens list embryos by patient with oocyte maturation, final grade, final day and disposition visible without opening a record, and the embryo state is tracked separately from soft deletion — available, transferred, frozen, biopsied or discarded.
- Oocyte maturation recorded as MII, MI, GV or degenerate
- Sperm source: partner, donor, TESE, PESA or frozen
- Disposition: transferred, frozen, discarded, biopsy, donated or arrested
- PGT result written back from the genetics domain
Daily observation is where grading actually happens
Morphology assessment is a repeated observation, not a single verdict, and a record that only stores the final grade throws away the developmental history that explains it. The daily observation grid holds one row per embryo per culture day and is embedded directly in the embryo form and detail view, with fixed rows for days 2 through 6 and columns for cell number, pronuclei, fragmentation percentage, symmetry, morphology grade, expansion, ICM, trophectoderm and the action taken. The morphology dropdown changes catalogue with the day, so a day-3 row offers day-3 cleavage grades and a day-4 row offers morula-stage descriptors. The schema stores days 0 to 7, so day-0 insemination and day-1 fertilisation-check rows can be held against the embryo even though the grid surfaces days 2 to 6.
Gardner grading, kept structured
Blastocyst grading is three independent judgements — degree of expansion, inner cell mass quality, trophectoderm quality — and clinics that store them as a single free-text string lose the ability to query any one of them. FertiliCore keeps them as three fields on the observation row: expansion 1 to 6, ICM A to C, trophectoderm A to C. There is deliberately no blastocyst pick-list; the Gardner system is captured structurally instead. The same row carries an AI morphokinetic score field, which is what a time-lapse incubator export populates when the device connector is configured.
Biopsy and the hand-off to genetics
Three biopsy techniques are modelled, matching what laboratories have actually done over the past two decades. Blastomere biopsy records the culture day, cells removed and cells sent. Polar body biopsy records whether PB1, PB2 or both were taken. Trophectoderm biopsy — the technique behind current PGT-A and PGT-M work — records the day, the cell count, the tube identifier used for chain of custody, whether the sample has been shipped, and which genetic centre received it. These are held in the data model and served through the API rather than through a dedicated biopsy screen today; the resulting PGT verdict returns to the embryo record as its PGT result.
Transfer, cancellation and warming
Transfer is the event a cycle turns on, and the details that matter for later audit are procedural: who transferred, on what day of development, through which catheter, into what endometrium. The embryo transfer screen records the date and time, the physician and loading embryologist, the number of embryos and the transfer day, catheter type, endometrial thickness in millimetres, procedural difficulty and, when the transfer did not proceed, a coded cancellation reason from a seeded list. Which specific embryos were placed — number, grade, day, and whether each was frozen-thawed — is modelled as per-embryo transfer lines held against the transfer. Embryo thaw sessions are recorded on their own screen with embryos warmed, survived and damaged and the warming protocol used, which is what makes thaw survival rate reportable.
- Coded ET cancellation reasons, including freeze-all and PGT pending
- Endometrial thickness and transfer difficulty on every procedure
- Thaw sessions with survived and damaged counts
Field level
What the record actually holds.
Structured fields, not a free-text note — which is what makes the reporting and the registry returns downstream possible.
Embryology session
- Linked cycle, OPU and clinical visit
- Session date and responsible embryologist
- Insemination method and sperm source
- MII, MI, GV and degenerate oocyte counts
- Normally fertilised 2PN count
- Abnormal fertilisation count (1PN, 3PN)
Embryo record
- Embryo number within the session
- Oocyte maturation and morphology references
- Sperm source, morphology and motility notes
- Final grade and final assessment day
- Freeze day and cryopreservation method
- Thaw date, transfer date and disposition
- Discard reason where applicable
Daily observation
- Culture day, 0 to 7 in the data model
- Cell number and pronuclei count
- Fragmentation percentage, 0 to 100
- Blastomere symmetry
- Day-specific morphology grade from the catalogue
- Gardner expansion, ICM and trophectoderm
- AI morphokinetic score
- Action taken and action time
- Assisted oocyte activation flag and method
Fertilisation and biopsy
- Pronuclear pattern, PN count and polar body count
- Per-embryo sperm morphology classification
- Per-embryo sperm motility grade and percentage
- Blastomere biopsy: cells removed and cells sent
- Polar body biopsy: PB1 and PB2 removal
- Trophectoderm biopsy: day, cell count, tube identifier
- Shipment flag and receiving genetic centre
Embryo transfer
- Transfer date, time and treatment cycle
- Performing physician and loading embryologist
- Number of embryos and transfer day
- Catheter type used
- Endometrial thickness in millimetres
- Endometrial pattern reference
- Procedural difficulty
- Coded cancellation reason
- Per-embryo lines with grade, day and frozen flag
Thaw, discharge and imaging
- Thaw date and performing embryologist
- Embryos thawed, survived and damaged
- Warming protocol used
- Discharge summary with frozen, transferred and discarded counts
- Clinical recommendations and signing doctor
- Embryo images keyed to the observation day
Common questions
How is embryo grading recorded — free text or a controlled scale?
Cleavage and morula stages use seeded pick-lists: a day-2 catalogue, a day-3 catalogue and a day-4 morula catalogue, with the daily observation grid switching catalogue according to the row's culture day. Blastocysts are graded structurally instead of by pick-list, with expansion, inner cell mass and trophectoderm held as three separate fields. That means you can query on trophectoderm grade alone, which a single free-text grade string does not allow.
Can we import morphokinetic data from a time-lapse incubator?
Yes. The LIS and device connector imports EmbryoScope, Geri and MIRI morphokinetic exports as CSV or XML and maps them onto the daily observation rows, including the AI score field. The same connector handles ASTM and HL7 ORU results from analysers. Ingestion runs through a watched folder or a TCP listener, and it stays off until an endpoint is configured.
Does FertiliCore provide electronic witnessing at each handling step?
No. There is no barcode or RFID electronic witnessing tied to individual gamete and embryo handling steps today, and we would rather say so than imply otherwise. What exists is lot and consumable traceability, the tube identifier on trophectoderm biopsy for chain of custody, and a full audit trail recording who entered or changed each record and when. Records can also be locked to make them read-only once finalised.
How does a biopsy connect to the PGT result?
Trophectoderm biopsy records the embryo, the biopsy day, the number of cells removed, the tube identifier and the genetic centre the sample was sent to, so the physical sample stays traceable to the embryo it came from. When the genetics domain returns a verdict it is written back to that embryo's PGT result field. The biopsy tables are modelled and exposed through the API rather than through a dedicated biopsy screen at present.
Which embryology areas have data-entry screens today?
Embryo records with the daily observation grading grid, embryo transfer, and embryo thaw sessions are built screens behind the embryology permission module. The session header, pronuclear scores, the three biopsy types, per-embryo transfer lines, the discharge note and embryo photos are modelled and served through the API but do not yet have their own entry screens. The report catalogue already renders from those tables, so data loaded via the API appears on the printed documents.
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